Scientists have discovered a promising target that can be used to treat high-invasive brain tumors in infants.
Scientists from the Stanley Manner Children's Institute at the Ann Lloyd Children's Hospital in Chicago, Ontario, have discovered a promising target through the use of state-of-the-art genetic editing techniques. This target can be used to treat atypical teratoma/rhabinosarcoma (AT/RT), a highly aggressive and refractory brain tumor that occurs primarily during infancy. They found that the growth and metastatic propensity of these tumors was regulated by Polo-like kinase 4 (PLK4) protease, which increased in atypical teratoma/rhabinosarcoma. They also confirmed experimental drugs, that is, PLK4 inhibitors can inhibit tumor growth. These findings were published in Pediatric Blood & Cancer.
Siamne T., Associate Professor and First Author of Pediatric Neurosurgery, Northwestern University's Fenberg Cancer Research Institute, Stanley Manley Children's Institute, Ann Lloyd Children's Hospital, Chicago, USA Sredni, MD, said: "This is the first time that PLK4 has been found to be a therapeutic target for brain tumors and childhood cancer.
Using a new gene editing technique called CRISPR/Cas9, Sredni and his team identified PLK4 as a potential target for treatment. It allows them to mutate a single kinase gene, the major regulator of cellular function, to identify kinases that affect tumor cell growth. They then turned their attention to the current kinases that are testing the corresponding inhibitors that are treating breast cancer.
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