Release date: 2017-09-13
Researchers have found a revolutionary way to treat disease, and with an electronic implant it is possible to eventually reduce or even end the medications of some patients. This technique relies on electrical stimulation of the vagus nerve, which extends from the brain to the abdomen and is connected to organs such as the heart, spleen, lungs, and intestines. It transmits signals from the body's organs to the brain and can also be transmitted in the opposite direction.
This pacemaker-like device is usually implanted under the left clavicle and attached to the vagus nerve in the neck. This device has been used to treat more stubborn epilepsy and depression. But a new research team claims that such a neural circuit that accesses the body may slow the symptoms of rheumatoid arthritis and Crohn's disease.
Researchers say the technology has the potential to bring new hopes to diseases that are incurable, and it may allow patients to reduce their medications and eventually stop taking them. Kevin Tracey, co-founder of biomedical company SetPoint Medical and head of the Vanstein Medical Research Center, said: "We will see millions of people implanting this device in the future so they don't have to continue taking the drug."
Even more encouraging, last year Tracey and colleagues conducted clinical trials on 17 volunteers with rheumatoid arthritis. More than 2 / 3 participants achieved at least a 20% improvement, 2 of whom recovered. One of the participants, Monique Robroek, said: "I didn't feel any pain in the 6 weeks, the joint swelling disappeared, I started cycling, walking the dog and driving, everything was like magic."
This field is called “bioelectronics†by scientists, and research teams around the world are involved in research in this field. Technology companies such as General Electric, GlaxoSmithKline and Google are also involved in this field. The National Institutes of Health has also established a $20 million bonus for this area.
Bioelectronics accomplishes this by manipulating neural circuits. This method is based on the “inflammation reflexâ€, in which information about tissue damage and inflammation is transmitted to the brain through the vagus nerve, and then the brain signal is sent back to the organ in reverse to suppress inflammation.
The researchers say that the key to treating diseases such as rheumatoid arthritis is tumor necrosis factor, which is released by macrophages, but its toxic side effects are too strong. Drugs currently used to bind tumor necrosis factor and inhibit its activity are huge opportunities, but these drugs are not suitable for all patients, and the side effects of drugs can increase the risk of cancer. The electronic biology method closes the release of tumor necrosis factor by stimulating the vagus nerve.
Matthijs Kox, an expert in the field of immunoreaction at the University of Nijmegen Medical Research Center, said: "This is a very exciting research finding, because for decades we have thought that the brain has no effect on our immune system." Tracey thinks this The new medical technology can help us alleviate the symptoms of many diseases, such as high blood pressure, cancer and sepsis. He uses the tip of the iceberg to describe the current research findings.
Source: NetEase Technology
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