Release date: 2018-04-08
According to a recent article published in the journal Obstetrics & Gynecology, mRNA detection is less sensitive than HPV's DNA detection.
In this study, Sarah Cotton and colleagues from the UTHealth McGee School of Medicine in Houston, USA, analyzed data from pathology laboratories, including DNA testing and multiple mRNA assays to identify patients over the age of 30. Information on female HPV patients.
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In this study, scientists analyzed a total of 425 cases of women over the age of 30. The results showed that the difference in HPV mRNA detection results was 69.3% compared with the HPV DNA positive test results. Subsequent studies showed that patients with a high-risk positive and more than two high-risk positives were 71.7% and 60.0%, respectively. . A total of 26.8% of the 231 colposcopy findings were abnormal, of which 25 (40.3%) were patients who were positive for the two HPV DNA tests and negative for the most recent mRNA test.
"Based on the above results, we believe that mRNA detection methods should not be used as a detection tool for HPV primary screening," the researchers said.
Information Source: mRNA assay less sensitive than DNA assay for latent HPV
Source: Bio Valley
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