A new gene regulates cholesterol absorption in humans
July 02, 2018 Source: Health News
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Professor Song Baoliang, Dean of the School of Life Sciences at Wuhan University, teamed up with Professor Ma Yijun from Xinjiang Medical University to discover a new gene that regulates cholesterol absorption in the body. The research paper of the research was published in the American international academic journal Science.
Elevated levels of low-density lipoprotein cholesterol in the blood are the main risk of cardiovascular and cerebrovascular diseases. Cholesterol levels are primarily influenced by diet, lifestyle and genetic factors. There are differences in the frequencies and loci of genetic variation among different ethnic groups and different populations. Through the epidemiological investigation, the research team found that some people in the Kazakh ethnic group in Xinjiang Uygur Autonomous Region have protective genes and mutations. The genetic mutation carriers have health indicators in addition to lower cholesterol levels. The researchers selected a Kazakh family to isolate the genomic DNA of the family members and conduct a research analysis. Finally, a new mutation site was found in people with low blood lipids, located in a gene called LIMA1, which is related to the cholesterol concentration in them. Low correlation.
The team conducted a more in-depth study. Analysis of variant carriers suggested that their cholesterol absorption decreased, and this finding was confirmed and reproduced in knockout mice. Through molecular-level research, the research team further revealed the function and mechanism of new gene-mediated cholesterol absorption in the small intestine.
The study provides a new drug development target for cholesterol lowering, and also helps to understand why Kazakh people consume more beef and mutton, but the prevalence of cardiovascular and cerebrovascular diseases is lower than that of the Han population. (Reporter Mao Xu correspondent Wu Jianglong)
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