Release date: 2018-07-10
Acoustic kinetic therapy can rapidly change plaque composition, reduce plaque area and increase arterial lumen within 1 week. Its efficacy is significantly better than statin drugs, and it will not cause plaque rupture and thrombosis, and will not cause skin at the treatment site. Damage to tissues such as muscles and nerves. The team of the Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, has made new progress in the application of acoustic-dynamic therapy for the treatment of atherosclerotic plaque. Related articles have recently been published in the latest issue of the European academic journal Cardiovascular Research. Experts pointed out that as a new interdisciplinary technology combining science, engineering and medicine, acoustic and dynamic therapy has shown good prospects in the prevention and treatment of atherosclerotic diseases.
Atherosclerosis is an invisible killer lurking in the cardiovascular system. Incidence and lethal disability rate are increasing year by year; especially atherosclerotic plaque, causing arterial stenosis during continuous progression, leading to a series of acute Malignant vascular events such as myocardial infarction, stroke, and gangrene of the lower extremities seriously affect people's quality of life and endanger life and health. At present, the treatment strategy for atherosclerosis is mainly based on cardiovascular medication and interventional therapy. Among them, the efficacy of statin lipid-lowering drugs is widely recognized, but its role in reversing plaque is limited, and may lead to liver and kidney dysfunction. Interventional methods are invasive, and there are also shortcomings such as high surgical risk, expensive medical consumables, and high postoperative stenosis rate.
Acoustic kinetic therapy is an emerging medical technology that combines ultrasound with drugs (sound sensitizers). Thanks to the high-frequency penetration of low-frequency ultrasound on biological tissues, acoustic energy can be transmitted to deep tissues on the surface, through activation and aggregation. A porphyrin-type sound sensitive agent in a target tissue or cell produces a reactive oxygen molecule, which in turn induces cell death or regulates cell function, thereby achieving a therapeutic effect. In the related animal experiment research, Professor Tian Xin and members of the research team, Sun Xin and Guo Shuyuan, confirmed that the vocal motility therapy can quickly change the plaque composition and reduce the plaque size within 7 days through the rabbit atherosclerotic plaque model. The narrow arterial lumen is significantly enlarged. At the same time, the atherosclerotic plaque model of the knockout mouse is used to reveal that the mechanism of acoustic kinetic therapy is related to the selective induction of macrophage apoptosis and plaque inflammation. This article also reported for the first time in the world a pilot clinical trial of patients with lower extremity and carotid atherosclerosis. The results showed that acoustodynamic therapy combined with atorvastatin can significantly reduce atherosclerosis within 4 weeks. Plaques, and the effect lasts for at least 40 weeks.
The field team is currently conducting two prospective clinical studies, including Acoustic Dynamic Therapy for Lower Extremity Arteriosclerosis Obliterans and Acoustic Dynamic Therapy for Carotid Atherosclerotic Plaques, with the aim of using a variety of imaging and functional tests. Means to verify the effect of acoustic motility therapy on alleviating intermittent claudication symptoms, improving carotid atherosclerotic plaque components, and reducing plaque volume, so that this new technology can "flowering results" in the clinic as soon as possible, benefiting the vast atherosclerosis Patients with sclerotherapy. (Reporter Yi Xiaofeng correspondent Sheng Lijian)
Source: Health News Network
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