Studies have found that specific genes can cause cancer cells to sleep

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Studies have found that specific genes can cause cancer cells to sleep

May 06, 2019 Source: Xinhuanet

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Xinhua News Agency, Sydney, April 30 (Chen Yu), an international research team recently reported that they have discovered key genes that can make certain cancer cells dormant. Whether these genes work or not is related to the microenvironment of cancer cells. The outcome is expected to help prevent metastasis and recurrence of specific cancers in the future.

According to reports, after the cancer cells are dormant, the human immune system is difficult to identify and attack, and it is difficult for chemotherapy drugs to exert their effects. Therefore, dormant cancer cells are a major risk factor for cancer metastasis and recurrence.

One of the leaders of the study, Associate Professor of the Canadian Gavin Medical Research Institute, told the Xinhua News Agency that the medical community has been trying to figure out the mechanism by which cancer cells go to sleep, which helps to develop targeted drugs and identify them. And kill these cancer cells.

Researchers at the Gavin Medical Institute and the team of the Weizmann Institute of Science in Israel published a paper in a new issue of the American journal Blood, which used a two-photon microscope to identify dormant bone marrow in experimental animals. Tumor cells.

The researchers performed a genomic analysis of dormant myeloma cells to identify all activated genes and found that some of these specific genes were not normally activated in non-dormant cancer cells. Further studies have found that these specific genes enable dormant cancer cells to release genetic markers similar to human immune cells, thereby evading immune system and drug attacks, and these gene markers are only released when cancer cells approach osteoblasts. Researchers believe this shows that the microenvironment in which cancer cells are located has a critical impact on whether it is dormant.

"Our approach is different in that we study cancer cells and their ecosystems as a whole. We find that not only the cancer cells themselves, but also the microenvironment in which they are located will determine whether they are dormant." reporter.

The researchers said that the next step will be to use this work to try to find out the genetic markers released by other kinds of cancer cells when they enter dormancy, hoping to find common features, and to develop targeted therapies specifically for dormant cancer cells.

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