"Parkinson's disease is not as simple as it was when it first started, involving multiple systemic degeneration of multiple neurotransmitter networks. Abnormal changes in the cerebellar network may also be involved in certain motor symptoms. Fortunately, dopamine can improve exercise. Energy is enough to improve exercise control, but ultimately other degenerative changes are more important.†On the 12th, at the first China Parkinson League Conference and the 3rd International Symposium on Exercise Control and Parkinson's Disease, the National Institutes of Health Professor Mark Hallett, director of the Human Motion Control Department at the Institute of Neurology and Stroke, said.
Professor Chen Wei, director of the National Center for Geriatrics Clinical Research (Xuanwu) and chairman of the China Parkinson Alliance, said that with the aging of the population, Parkinson's disease, which mainly affects the motor function of the elderly, has become a serious threat to the health of the elderly. The third biggest killer. Epidemiological studies have shown that the prevalence of Parkinson's disease in people over 65 years old is 1.7%. There are nearly 3 million Parkinson's patients in China, and they suffer from motor dysfunction such as tremor, muscle stiffness and bradykines all year round. The number of patients with Parkinson's disease in China has accounted for more than half of the world's total, and less than one million patients have been diagnosed and treated.
Parkinson's disease in China is still in the "three low" state of low awareness rate, low rate of diagnosis, and low diagnosis and treatment rate, especially in small and medium-sized cities and rural areas. The main reason is the lack of Parkinson's disease specialist. There is no effective cure for Parkinson's disease, which has the characteristics of long course of disease, high disability rate, and heavy burden on family and society.
"Dopamine can explain the movement characteristics of Parkinson's disease. For example, it can explain the general movement of Parkinson's disease and some exercise problems, but it can't explain the sequence effect and scaling obstacles; it can explain the stiffness, but it can hardly explain the tremor; it can also explain a small Some postures are unstable and gait.†Mark Hallett said that dopamine replacement therapy and deep brain stimulation surgery can improve patients' clinical symptoms, improve their quality of life, and enable the elderly to live well and live. Long.
In November 2017, the China Parkinson Alliance was established. Chen Wei introduced that the alliance has successfully developed PET molecular imaging probes for clinical detection of senile plaques and dopamine neurons, and has been applied to more than 500 clinical patients and new drug registration multi-center clinical trials. (Ma Aiping)
Source: Technology Daily
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