Why is depression often associated with sleep problems? The international team led by scientists at Fudan University gives answers to this question at the level of the brain and nerve mechanism. The results of the study showed that the lateral orbitofrontal cortex, wedge leaf and dorsal prefrontal cortex and other brain regions together constitute the basis of the cranial nerve circuit of depression and sleep quality. This study is expected to revolutionize the quality of sleep in patients with depression and even revolutionize the treatment of depression.
By integrating the international brain image database - the American Brain Connect Group Program and the British Biobank, the researchers analyzed data on image behaviors of nearly 10,000 subjects and found that the lateral orbitofrontal cortex of people with poor sleep quality (negative Signal synchrony (functional connection) in the brain regions such as the emotion-related brain function area, the wedge leaf (self-related brain function area), and the dorsal prefrontal cortex (short-term memory-related brain function area) is significantly increased; These neural circuits also showed a significantly elevated pattern in people with higher depression scores. It is these synchronic enhancements that modulate the relationship between depression and sleep.
In this regard, Feng Jianfeng, dean of the Institute of Brain Intelligence Science and Technology of Fudan University, explained the possibility that the connection enhancement of these brain regions may cause this group of people to be in some negative emotions for a long time, which leads to a decline in sleep quality. (According to Xinhua News Agency)
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