Professor Yasuyuki Fujita of the Institute of Genetic Medicine of Hokkaido University constructed RasV12 cancerous cells. When RasV12 cancerous cells were placed in normal cells, the mitochondrial membrane potential in the cells decreased, and glucose uptake increased, resulting in intracellular A higher level of lactic acid is produced.
Since mitochondrial dysfunction is caused by up-regulation of pyruvate dehydrogenase kinase 4 (PDK4), it suggests a positive effect of PDK4 in EDAC.
Using a cell-competitive mouse model, the authors demonstrated that PI3K-mediated metabolic changes promote the clearance of RasV12 cancerous cells. In vitro and in vivo experiments revealed two metabolic changes that occur within newly transformed cells: mitochondrial dysfunction and elevated glucose uptake. And these changes only occur in newly transformed cells surrounded by normal epithelial cells. Explain that these two changes are caused by normal cells.
Dynamic cell microscopy video shows that new cancer cells retreat in the initial cell competition due to the exclusion of surrounding normal cells.
According to the report, metabolic changes play an important role in the clearance of early cancerous cells. Interestingly, however, this metabolic change in the early stages of cancer is very similar to the Waberg effect that occurs in the advanced stages of cancer. It is generally believed that the Waberg effect promotes the development of cancer, but the researchers found that this metabolic change similar to the Waberg effect will limit the survival of early tumor cells.
YT-H711
YT-H711
Shenzhen Sunshine Technology Co.,Ltd , https://www.szyatwin.com