Basophils are closely related to the pathogenesis of chronic obstructive pulmonary disease

Basophils are closely related to the pathogenesis of chronic obstructive pulmonary disease

December 21, 2018 Source: Science and Technology Daily

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A team of doctors at the Tokyo Medical and Dental University in Japan, using an animal model of COPD (chronic obstructive pulmonary disease), found that basophils of one of the rare blood cells formed a characteristic lung injury (emphysema) in chronic obstructive pulmonary disease. Has played an important role.

The team found that monocytes that invade the lungs become interstitial macrophages under the action of IL-4 substances secreted by basophils, and MMP-12 proteolytic enzymes produced by mesenchymal macrophages. The lung tissue is damaged, thereby forming emphysema.

Previously, there was no cure for chronic obstructive pulmonary disease, and the formation of emphysema in the early stage was still unclear. This study clarified this process at the cellular and molecular levels. Using this result to analyze the formation of the slow-resistance lung in the human body in detail, it is expected to develop new preventive methods and therapeutic drugs.

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