Pharmacological effects
1. Effects on the Central Nervous System Paeoniflorin has a significant analgesic effect on the acetic acid-induced writhing response. In combination with the licorice methanol complex, the two have a synergistic analgesic effect on the acetic acid writhing response. TGP has a synergistic effect on morphine and clonidine in inhibiting writhing in mice. The analgesic effect of total peony of Angelica dahurica can not be blocked by naloxone, nor does it affect the contraction of longitudinal muscle of guinea pig guinea pig stimulated by low-frequency electric field. It is suggested that the analgesic effect of ferrets is not caused by excited opioid receptors. Total peony (1-40 mg/kg) inhibited writhing, squeaking, and hot plate reaction in a dose-dependent manner, and prolonged the incubation period of rat hot plate reaction. The peak effect was 0.5 to 1 hour. The different pain indicators reflect the different functional activities of the pain integration center, the tail flick reaction is mainly done by the spinal cord, and the squeals and squatting are completed at the senior center and can reflect the emotional activity to some extent. There was no obvious effect on the tail flick reaction, but it could suppress bark and callus reaction, indicating that the site of the general callus was at the senior center.
The total fleas of white peony can significantly inhibit the activity of mice; it also has a significant inhibitory effect on the irritated mice induced by electrical stimulation.
Intraperitoneal injection of total peony (5-40 mg/kg) can reduce the normal body temperature of mice and rats in a dose-dependent manner. The peak effect is 0.5 to 1 hour. The cooling effect is affected by the environment. The intracerebroventricular injection of trace total glycosides (2.4mg/kg) also showed significant cooling effect. The H1-receptor blocker chlorpheniramine (10mg/kg, 20mg/kg subcutaneous injection) can significantly antagonize the cooling effect of total pupa against rats and mice. Therefore, some people believe that the cooling effect of the total pupa of the white peony is related to the sensitization of H1-receptors in the brain. However, total peony (40 mg/kg intraperitoneally or subcutaneously) has no significant cooling effect on normal guinea pigs and rabbits.
2. Effects on the cardiovascular system Phlegm water solution can significantly prolong the survival time of myocardial hypoxia induced by isoproterenol; counteract the electrocardiographic changes caused by pituitrin; increase the nutrient blood flow of mouse myocardium.
In vivo experiments showed that the white peony has the effect of constricting blood vessels and increasing the peripheral resistance. The total pupa of the white peony can increase the diastolic blood pressure of the rabbit, increase the dp/dtmax, and the heart rate is slowed down. The phentolamine has no blocking effect on its boost pressure. , It also enhances the effect of NA boosting to enhance the heart sound intensity. However, the total fleas on the isolated ear veins of rabbits can expand them, increasing the number of droplets per minute and the volume (ml); there is no obvious effect on isolated rabbit aortic strips, but it can significantly increase NA The contraction of rabbit aortic strips.
3. The antispasmodic effect of anticonvulsants has a good antispasmodic effect. Its antispasmodic effect is the result of its direct action on intestinal smooth muscle. The leaching solution of paeoniflorin and paeoniflorin have inhibitory effects on the isolated small intestine of isolated guinea pigs and reduce the tension. There is no obvious effect on the contraction of intestinal tract caused by acetylcholine, but it can inhibit intestinal contraction caused by barium chloride. Through the study of the antispasmodic effect of peony and licorice decoction, it was suggested that the white peony inhibited the release of acetylcholine from the parasympathetic nerve endings with presynaptic inhibition. The role of peony is thought to be related to adenosine-like substances, but theophylline does not completely inhibit the action of peony, so the role of peony in addition to adenosine-like substances, there are other substances involved.
The glycosides of Paeonia lactiflora had excitatory effect on uterine motility in mice at low concentrations, but inhibited at high concentrations. 3. Pedicel has a significant inhibitory effect on oxytocin induced uterine contractions.
4. Protection of the liver The extract of Angelica falciparum has obvious antagonistic effects on D-galactosamine-induced liver injury and elevation of SGPT, which can reduce SGPT and restore normal liver lesions and necrosis. The ethanol extract of Angelica dahurica can reduce the increase of the total activity of lactate dehydrogenase and isoenzymes in acute liver injury induced by aflatoxin B1 in rats. The total peony can inhibit the increase of plasma GPT and lactate dehydrogenase in mice induced by carbon tetrachloride, and has a certain antagonistic effect on hepatic tissue phagocytic degeneration and necrosis. Some people think that carbon tetrachloride-induced liver damage is caused by the over-oxidation of the cell membrane structure, which results in elevation of blood alanine aminotransferase and lactate dehydrogenase, and that the total fleas may have protective effects on hepatocyte damage. Reduces transaminases.
5. Anti-inflammation experiments showed that total peony has significant preventive and therapeutic effects on adjuvant arthritis in rats, and at the same time, excessive levels of hydrogen peroxide and interleukin-1 were reduced in rat peritoneal macrophages. It can normalize the hypothyroid mitogen response induced by adjuvant arthritis in rats and the production of interleukin-2 by splenic lymphocytes. 5. It is suggested that total peony has anti - inflammatory and function - dependent immunoregulatory effects on adjuvant arthritis rats. Bletilla striata extract can significantly inhibit rat egg white acute inflammation edema, and also inhibit the proliferation of cotton ball granuloma.
6. Studies on the effects of the immune system have shown that Angelica can enhance the phagocytosis of macrophages. Each day, the mice were fed with 50% white peony decoction of 0.8 ml per mouse. For 5 consecutive days, the phagocytosis percentage and phagocytic index of the mouse peritoneal macrophages were significantly higher than those of the control group. Daily gavage of mice with 40 mg/kg total peony can also promote the phagocytic function of peritoneal macrophages. Experiments show that the total pueraria of the white peony can regulate the phagocytosis of peritoneal macrophages; the total peony of the white peony has the effect of promoting the production of interleukin-1 in rat peritoneal macrophages with low concentration and high concentration inhibition. Since interleukin-1 plays an important role in the immune regulation and the formation of chronic inflammatory diseases, it can be considered that the regulation of interleukin-1 production by total peony may be the use of immune regulation and prevention of arthritis. One of the mechanisms. Experiments have also shown that total peony has inhibitory effects on leukotriene B4 produced by rat peritoneal macrophages in a dose-dependent manner, with 100 mg/L of inhibition and the same dose of non-steroidal anti-inflammatory drugs. Acid is quite, but it is slower. The 50% inhibition rate was 0.66 mg/L; therefore, the anti-inflammatory and immunoregulatory effects of total peony from peony may also be related to the production of leukotriene B4.
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