There are many clinical trials currently underway in the world (including first to third generation CAR). In addition to CD19, what other targets are used for CAR-T treatment of tumors? Today, Xiao Bian makes a comprehensive summary of the targets used in CAR-T clinical use, the corresponding tumor types, receptor types, and the generations of CAR technologies used, and hopes to have reference significance for wheat flour.
CAR-T (chimeric antigen receptor T cell immunotherapy), a new type of cell therapy that has been used for many years but has been improved and used clinically in recent years. It has significant efficacy in the treatment of acute leukemia and non-Hodgkin's lymphoma and is considered to be one of the most promising treatments for cancer.
Due to the high sensitivity of CAR-T therapy, its targeted/off-target toxicity leads to more serious side effects than traditional antibody drugs. Therefore, the target selection of CAR-T therapy cannot be applied to the target selection criteria of traditional antibody therapy, but it is necessary to find a more stringent tumor-specific antigen as a target.
Needless to say, the most successful case of CAR-T is a series of clinical trials targeting B cell tumors targeting CD19. Clinical trials have shown that CD19 CAR-T has a cure rate of 90% for acute B-lymphocytic leukemia (B-ALL).
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With the improvement of people's living standards, people pay more and more attention to the importance of physical health. More and more people will use their spare time to exercise, run, ride, climb mountains and so on.
But then comes the safety of sports. A little too much force or improper operation will cause injury. It was originally for the sake of health, but it was only a few days after exercise, which is a bit more than worth the loss.
Nowadays, more and more people begin to pay attention to their health. Running has become the first choice of most people because of its relatively low technical threshold. With the rise of running craze, a variety of equipment has also quietly jumped into the sight of runners, from professional running shoes, sweat-absorbing clothes and pants, wearable electronic devices, and shin and patella band and other protective devices. Running is often prone to sprains, falls and other accidents. Choosing a knee pad that can protect the body is very important.
For runners, there are also several common injuries, such as knee pain, iliotibial tract syndrome, foot blister, sprain wait. How did you solve or avoid the pain problem?
Knee pads and waist support are very good for sports injuries&protective equipment
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