A team of scientists at the University of Queensland has made new advances in gene therapy by successfully targeting specific immune cells by injecting specific genes into hematopoietic stem cells to "disappear" certain severe allergic reactions. For patients with severe allergies, their immune cells (T cells) will "memorize" specific proteins of a particular allergen. Once formed, they will produce a strong immune response after exposure to allergens. The key is to clear the memory in the immune cells.
Professor Ray Steptoe, who led the research team at the University of Queensland, explained, “We used hematopoietic stem cells and injected genes that regulate allergen proteins into the receptor. Engineered cells can generate blood cells that express the protein, targeting Clear specific immune cells to 'eliminate' allergic reactions"
In the laboratory mouse test, the research team has successfully passed the therapy to 'close' an established asthmatic allergic reaction in mice. Professor Ray Steptoe believes that the therapy is expected to be applied to other more serious allergic reactions such as peanuts, bee stings, and shellfish. Of course, the current research is still in the early experimental stage, and at least five years can be transferred from scientific experiments to preliminary human trials. If the research is successful, asthma and other fatal allergic reactions may be treated once in 10-15 years.
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