Release date: 2018-06-21
Science and Technology Daily, Beijing, June 20 (Reporter Zhang Mengran) The British "Nature·Communication" magazine published a new development in synthetic biology on the 19th: a team of European scientists designed a new synthetic biology gene loop and proved that it can pass coffee Due to the activation of this synthetic gene loop. Mouse diabetes model studies have shown that it can successfully regulate blood glucose levels. The research results may help humans fight diabetes, and also demonstrate the potential of synthetic biology in the medical community.
Synthetic biology can solve many problems in energy, materials, and environmental protection by designing and constructing artificial biological systems that do not exist in nature. In recent years, the medical community is also experimenting with gene therapy and cell therapy based on synthetic gene loops to achieve blood sugar regulation in the body environment, thereby helping to repair the physical condition of diabetics.
Type II diabetes accounts for more than 90% of all diabetic patients. Compared with type I diabetes, the ability of insulin to produce insulin in type II patients is not completely lost, but is in a relatively lacking state. Type II diabetes affects more than 400 million people worldwide and costs a lot of medical care. At present, humans have no cure for diabetes, and can only control the development of the disease through a variety of treatments. Among them, successful health management needs to be able to monitor the rise in blood glucose after eating, respond and control blood sugar levels.
This time, Martin Fusseneger, a researcher at the Federal Institute of Technology in Zurich, Switzerland, and colleagues studied whether caffeine can be used to induce gene expression to help regulate blood sugar. The research team designed a synthetic biological gene loop and named it "Caffeine Stimulating Advanced Regulator" (C-STAR), which responds to caffeine in commercial products to create a type II treatment. Peptide for diabetes.
Experiments have shown that in the mouse model of diabetes, cells carrying the C-STAR system successfully help control blood glucose levels after the mice ingested coffee.
The researchers said that although this is only a proof-of-principle demonstration, it shows that the genetic loop of synthetic biology design can use common compounds to regulate the body condition, and also shows the great potential of future synthetic biology in the field of health care, which is expected to be Lifestyle disturbances are minimized.
Source: Technology Daily
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