There is a "hole" in the heart that may cause a stroke.

There is a "hole" in the heart that may cause a stroke.

November 19, 2018 Source: China Youth Daily

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More than a decade ago, Israel had a very famous prime minister, Salon. He had outstanding military skills, strong style and great domestic and international influence. One day, Sharon suddenly felt unwell, his speech was unfavorable, his legs and feet did not listen, but he soon became better.

The doctor diagnosed the salon and got cerebrovascular disease. After a comprehensive physical examination of the salon, he found that the prime minister was in good health and had no high blood pressure, high blood fat and other diseases. He only had an abnormal "hole" in the heart - originally they were each other. Between the left and right atriums, because of this "hole", a "channel" for blood circulation is established, and this "channel" provides a convenient condition for the activity of blood clots.

After discussion, the team of the most famous stroke experts in the United States and Israel decided to perform an operation to block the unclosed "hole" in the heart of the salon. It is a pity that the 78-year-old man suddenly cerebral hemorrhage during the anticoagulation stage prepared before surgery and quickly coma. Afterwards, although there was some recovery, he eventually resigned from the post of Prime Minister. In 2014, Sharon passed away.

The medical name of the "hole" of this heart is called the patent foramen ovale. As the name implies, the foramen ovale should have been closed. When a person is born, many people have closed the foramen ovale. As they get older, 70% to 80% of the people have a long oval hole in their heart. Only a small number of people have ovals. The hole is in an open state, which is the patent foramen ovale.

Morphologically, the patent foramen ovale is like an unsecured door. Once the door is blown by the "wind", for example, the pressure difference of the blood flow, it can be opened. Once the door is opened, the brain tissue is exposed to potential thrombosis. In theory, some blood clots can go to the brain, block blood vessels, and cause stroke.

In the 1980s, scholars discovered the relationship between patent foramen ovale and youth stroke and cryptogenic stroke in European and American populations. In 2014, Chinese scholars also confirmed the patent foramen ovale through multi-center study, especially the correlation between the patent foramen ovale and the cryptogenic stroke. However, without a randomized controlled trial with a large amount of data, it is impossible to determine whether the patent foramen ovale is the "culprit" that directly causes stroke or indirectly causes stroke.

Fortunately, in 2017, the most authoritative New England magazine in the United States reported several clinical studies, confirming that patent foramen ovale closure can prevent cryptogenic stroke. More than 40 years later, the story of the patent foramen ovale finally came to an end.

Then the problem came. The patent for patent foramen ovale is an interventional procedure. Insert a tube from the thigh and walk all the way to the heart, then use the instrument to block the foramen ovale. It is ultimately a traumatic operation, and like the salon, many people are concerned about the risks posed by the surgery itself. Recently, many patients, especially young and middle-aged patients, went to the hospital for consultation of patent foramen ovale closure.

Since 2004, Peking Union Medical College Hospital has performed transcranial Doppler ultrasound diagnosis of patent foramen ovale. In 14 years, we have found a large number of subjects with cryptogenic strokes of patent foramen ovale. However, in the end, there were very few people who decided to recommend patients to perform occlusion.

The reason is simple. We want to prevent over-treatment: when the benefits of invasive medical interventions and the probability of victimization are comparable, it is even worse than conservative treatment. In the 2017 European and American clinical studies, the best outcome was to prevent a patient's stroke recurrence in every patient after 28 years of follow-up.

Most of these patients are patients with patent foramen with large diameter and are suitable for surgery. It is consistent with the data of China's multi-center study, that is, only the foramen ovale with large aperture is the pathological state, and the small foramen ovale is visible in normal people and does not need to be treated. Therefore, we should have the understanding that most of the young stroke or cryptogenic stroke patients do not have to undergo surgery immediately even if the patent foramen ovale is found.

At present, it is gratifying that many hospitals in China have carried out this patent for the treatment of patent foramen ovale; the Chinese youth stroke patients have access to the clinic. However, from another perspective, the operator's learning curve also takes a certain amount of time. Therefore, the occlusion of the foramen ovale should be “anti-left”: no patient's cause is accurately judged and highly selective, no surgeon is good. The ability to operate, this treatment can not be carried out quickly and extensively.

From the patient's point of view, don't be too anxious, because the recurrence rate of stroke caused by patent foramen ovale is also very low, and you can have enough time to make careful decisions. For the majority of young stroke patients, the patent foramen ovale is a minor contradiction to the control of traditional stroke risk factors (such as hypertension, smoking, hyperlipidemia). Therefore, smoking cessation, taking antihypertensive drugs and lipid-lowering drugs are still the most important things.

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