Aminoglycoside antibiotics or broad-spectrum drugs that are highly resistant to viruses and low in toxicity are expected to come out
April 10, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];A study published online in the journal Nature Microbiology on the 9th shows that a class of antibiotics used to treat bacterial infections can reduce the herpes, flu and Zika by stimulating host cells to form an antiviral state. The susceptibility of the virus. This discovery reveals a new way to activate antiviral defenses.
Antibiotics have anti-pathogenic or other active effects that interfere with the developmental functions of other cells. Currently, antibiotics are widely used to treat human bacterial infections, but their direct effects on the human body are still little known. Because of their potential toxicity, aminoglycoside antibiotics are mainly used in hospitals for the treatment of life-threatening bacterial infections and as a topical drug for eye and ear infections.
This time, Yahoo University researcher Iwasaki Akira and colleagues reported that topical aminoglycoside antibiotics can improve host resistance to herpes simplex, influenza A and Zika virus before viral infection occurs in the nose and other parts. This antibiotic acts directly on mouse cells and does not depend on their microbiome.
The team found that aminoglycoside antibiotics can cause dendritic cells, the "sentinel" of the immune system, to secrete signaling proteins that induce resistance to the virus in the lung mucosa. It has been shown that the use of antibiotics only before infection can produce this effect. In addition, the effect is short-lived, and the ointment containing the aminoglycoside antibiotic may be accompanied by some protection against the virus, but the use of the aminoglycoside antibiotic to treat the viral infection does not provide any guarantee.
Still, the study shows how antibiotics can directly affect a patient's body and reveals an unexpected new way to activate antiviral defenses. The findings will also help to develop newer, less toxic new drugs, mimicking the effects of aminoglycoside antibiotics, as broad-spectrum antiviral drugs. (Reporter Zhang Mengran)
Editor-in-chief
Bacteria have their own metabolic system, and the metabolism of the virus is essentially accomplished by the host cell. In general, antibiotics can kill bacteria but not kill them. However, this study shows that antibiotics can activate the host's antiviral defense mechanism, reminding cells to initiate a level of readiness, that is, it "adds no increase," and it also comes with some degree of anti-viral effect. . Of course, this effect is very short and it has to be effective before it can be infected. However, scientists have begun to use this mechanism to develop broad-spectrum antiviral drugs. Behind every "unusual", there may be a seed of a great discovery.
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