The film coating process can be widely used in tablets, pills, granules, especially for Chinese medicine tablets with strong hygroscopicity, easy to crack, and spotted, and the film coating is compared with the sugar coating, which has the following advantages. :
1. Good quality. Since the film-forming agent and most of the auxiliary additives are polymer materials with excellent physical and chemical properties, the film-coated film pieces can be protected from moisture, light, taste and abrasion, and is not easy to be mildewed and easily disintegrated. Drug dissolution, bioavailability and drug expiration date have greatly expanded the countries and regions where drugs can be sold, which has effectively promoted drug exports, especially proprietary Chinese medicines.
2. Less weight gain. Only the core weight is increased by 2% to 4%, and the sugar-coated tablets (where the main auxiliary ingredients are talc powder that has been eliminated abroad) tend to increase the weight of the core by 50% to 100%.
3. Dry quickly. The coating operation time is short, generally only 2~3h, and the sugar coating is generally required for 16h. It is easy to operate and easy to grasp, especially for Chinese and Western medicines which are easy to destroy at high temperature.
4. Beautiful image. The appearance is beautiful, the color is bright, the logo is fresh and the image is vivid. The medicine core can adopt various flat curved shapes. The trademarks and logos of the enterprise can be directly punched on the medicine core. After the film coating is wrapped, it is still clear and obvious, which not only improves the corporate image, but also plays an anti-counterfeiting role.
5. Many varieties. The film coating has a wide variety of materials to choose from, and the coating formulation can be used to make film garments with different characteristics to change the release position of the core and the release characteristics of the drug. In addition to the gastric soluble film and enteric film, there are also orally soluble films (including tablets), sustained release films, controlled release films, and composite films (in addition to the drug core, the film also contains another main drug) and the latest types. Layer film, microporous membrane, osmotic pump coating, targeted drug delivery coating, which greatly enhances the efficacy.
6. Wide application. Now, film coating has been widely used not only for Chinese and Western medicine tablets and pills, but also for small tablets (Minitablet), pellets (Pellet), granules, soft and hard capsules and even pharmaceutical powders. Film-forming materials can also be used directly. In the film (such as the contraceptive film, that is, the film contains the main drug without the drug core), a suspension, and a hydrophobic drug dispersing agent.
7. standardization. The design, process, materials and quality of the film coated tablets can be standardized and computerized, which is especially important for GMP management and entering the international market.
8. Less pollution. The process can reduce or avoid dust flying in the workshop, which is conducive to environmental protection and labor protection, and can prevent pollution in the workshop. This is of great significance in complying with GMP cleanliness requirements under dynamic conditions.
9. More solvent. The coating agent generally uses water as a solvent to prepare a coating liquid, which not only reduces the cost, but also makes the operating environment more comfortable and safe, but only some non-aqueous solvents can be used for some drugs that absorb water quickly or are easily decomposed and deteriorated by water. There are many solvents available for this.
10. low cost. Although the price of film coating materials is more expensive than sugar and talcum powder, due to the small amount and labor saving (1 to 2 operators), the plant and equipment need less (only one standard factory and one coating pot). Saving materials and energy, so the overall calculation is not more expensive than the sugar coating.
1. Good quality. Since the film-forming agent and most of the auxiliary additives are polymer materials with excellent physical and chemical properties, the film-coated film pieces can be protected from moisture, light, taste and abrasion, and is not easy to be mildewed and easily disintegrated. Drug dissolution, bioavailability and drug expiration date have greatly expanded the countries and regions where drugs can be sold, which has effectively promoted drug exports, especially proprietary Chinese medicines.
2. Less weight gain. Only the core weight is increased by 2% to 4%, and the sugar-coated tablets (where the main auxiliary ingredients are talc powder that has been eliminated abroad) tend to increase the weight of the core by 50% to 100%.
3. Dry quickly. The coating operation time is short, generally only 2~3h, and the sugar coating is generally required for 16h. It is easy to operate and easy to grasp, especially for Chinese and Western medicines which are easy to destroy at high temperature.
4. Beautiful image. The appearance is beautiful, the color is bright, the logo is fresh and the image is vivid. The medicine core can adopt various flat curved shapes. The trademarks and logos of the enterprise can be directly punched on the medicine core. After the film coating is wrapped, it is still clear and obvious, which not only improves the corporate image, but also plays an anti-counterfeiting role.
5. Many varieties. The film coating has a wide variety of materials to choose from, and the coating formulation can be used to make film garments with different characteristics to change the release position of the core and the release characteristics of the drug. In addition to the gastric soluble film and enteric film, there are also orally soluble films (including tablets), sustained release films, controlled release films, and composite films (in addition to the drug core, the film also contains another main drug) and the latest types. Layer film, microporous membrane, osmotic pump coating, targeted drug delivery coating, which greatly enhances the efficacy.
6. Wide application. Now, film coating has been widely used not only for Chinese and Western medicine tablets and pills, but also for small tablets (Minitablet), pellets (Pellet), granules, soft and hard capsules and even pharmaceutical powders. Film-forming materials can also be used directly. In the film (such as the contraceptive film, that is, the film contains the main drug without the drug core), a suspension, and a hydrophobic drug dispersing agent.
7. standardization. The design, process, materials and quality of the film coated tablets can be standardized and computerized, which is especially important for GMP management and entering the international market.
8. Less pollution. The process can reduce or avoid dust flying in the workshop, which is conducive to environmental protection and labor protection, and can prevent pollution in the workshop. This is of great significance in complying with GMP cleanliness requirements under dynamic conditions.
9. More solvent. The coating agent generally uses water as a solvent to prepare a coating liquid, which not only reduces the cost, but also makes the operating environment more comfortable and safe, but only some non-aqueous solvents can be used for some drugs that absorb water quickly or are easily decomposed and deteriorated by water. There are many solvents available for this.
10. low cost. Although the price of film coating materials is more expensive than sugar and talcum powder, due to the small amount and labor saving (1 to 2 operators), the plant and equipment need less (only one standard factory and one coating pot). Saving materials and energy, so the overall calculation is not more expensive than the sugar coating.
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Henan Anbang Medical Supplies Co., Ltd. , https://www.anbangmedical.com