Finding new methods for evaluating the progression of hereditary nephritis
August 25, 2017 Source: Health News
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)]; The latest research results of the team of Professor Ding Jie from the First Hospital of Peking University and the team of Professor Roger Wiggins of the University of Michigan in the United States used podocyte counting to evaluate the progression of hereditary nephritis (Alport syndrome). Recently, in Kidney International. Published. According to reports, the study is a successful case of translational medicine research, and the results confirm that the podocyte counting method can effectively and sensitively evaluate the progression of hereditary nephritis. International peer review experts recommend that this method be widely promoted to facilitate effective monitoring of disease progression and evaluation of drug efficacy for progressive kidney disease such as hereditary nephritis.
Ding Jie introduced that hereditary nephritis disease only shows hematuria at the beginning, gradually appearing proteinuria and renal function decline, eventually renal failure, requiring dialysis or kidney transplantation treatment. Currently, the commonly used indicators for assessing disease conditions are limited to proteinuria and renal function, but In some patients with hereditary nephritis, when proteinuria or renal dysfunction occurs, it is difficult to control the disease. Traditional monitoring indicators do not reflect the severity of the disease in time. It is not known whether there is already a kidney abnormality in the early stage of the disease. Therefore, finding more ideal monitoring indicators is the key point in the diagnosis and treatment of hereditary nephritis.
Podocyte count, ie, staining, calculation, and urine specimen detection by renal biopsy, counting the number of podocyte loss. Professor Ding Jie and Professor Roger Wiggins' team work confirmed that the podocyte counting method can be applied to patients with various stages of hereditary nephritis (from very mild condition, only hematuria to severe disease, decreased renal function) The loss of podocytes, at the same time, the method is more sensitive than the common indicators such as proteinuria and serum creatinine, and preferentially reflects the changes of renal function in hereditary nephritis. This method can also provide important clues in the prediction of disease progression. Therefore, this method is expected to be an effective indicator for monitoring renal function changes in disease follow-up and drug clinical trials. (Reporter Fu Donghong correspondent Ding Fangrui Zhang Hongwen)
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