Application and Research of Microwave Sterilization in Oral Liquid Drugs
In recent years, a new nutraceutical product, oral liquid, has appeared on the market. It is well known that oral liquids contain sugar, biological agents and abundant nutrients, which are easily contaminated. Some oral liquids on the market, because they are not well sterilized, bacteria multiply during storage, produce gas, and users suffer poisoning and bottle explosion accidents during use. Some oral liquid manufacturers, in order to prevent bacterial growth, add preservatives to the oral solution, the results can not go abroad. The microwave sterilization method can effectively solve the above problems, and the oral liquid is analyzed by microwave sterilization method.
1) Sterilization effect
The traditional method is to sterilize with high temperature steam, which needs to be warmed to 120 ° C, and the bacteria can be killed above 20 minutes. And microwave sterilization:
A. Escherichia coli and Bacillus subtilis can be completely killed in the microwave field by heating to 70 ° C for 2 minutes.
B. Thermophilic Bacillus subtilis, which needs to be warmed to 100 ° C by the traditional method and kept for 30 minutes, can not be killed. In the microwave field, the temperature was 70 ° C and kept for 2 minutes, which was killed. User feedback indicates that sterilization is performed with a 5 kW microwave device, killing bacteria in 50 seconds, and killing bacteria in an 8 kW microwave device for 35 seconds.
2) Analysis of the comprehensive economic effects of equipment
It is estimated that there are currently 5,000 manufacturers of oral liquids in the country, and less than 5% of manufacturers use microwave equipment to sterilize oral liquid. If everyone can use microwave equipment for sterilization, it can not only improve the grade of the product, but also overcome the quality problems of the oral liquid. It can also save the country as a collective, and save a lot of manpower and material resources for the majority of oral liquid manufacturers.
A. Compared with the traditional sterilization process, the microwave sterilization equipment has low cost and small floor space. The traditional high temperature and high pressure equipment needs to be equipped with a boiler pressure cooker, which is expensive and covers a large area.
B. Microwave equipment consumes less energy, and high-temperature and high-voltage equipment consumes a lot of energy.
C, microwave equipment operators are small, only 2-3 people, and high temperature and high pressure equipment should be equipped with more than 10 personnel for operation and management.
D. Microwave equipment has low noise, while high temperature and high pressure equipment has pollution and noise, which seriously affects the surrounding environment.
E, microwave treatment oral liquid, is a low temperature sterilization, can retain the original nutrients, clear color, good taste; and high temperature and high pressure treatment of oral liquid, destroying the original nutrients, color turbidity, precipitation, poor taste.
In summary, the application of microwave in the oral liquid sterilization process is a challenge to the traditional medical process and a revolution in the pharmaceutical process. It is expected that all oral liquid manufacturers will adopt microwave oral administration in the near future. Liquid sterilization process
Attached: Guangzhou Xiangxue Co., Ltd. oral liquid experiment report
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