Pharmacological effects
1. Antiasthmatic effect of isolated tracheal smooth muscle test showed that Litsea cubeba oil (Liriodendron chinensis fruit volatile oil) 10μl/ml can relax the normal tracheal smooth muscle and acetylcholine or histamine-induced tracheal smooth muscle tracheal smooth muscle. Pre-added volatile oil can block acetylcholine and histamine-induced contraction. Perfusion with Locke's solution containing 1 μl/ml volatile oil increased the bronchoduorrhage volume of normal guinea pigs in the first 3 minutes. Gastric guinea pigs were given intragastric administration of 300 μl/kg and intraperitoneal injection of 170 μl/kg. The bronchospasm was caused by 5% acetylcholine spray. Obvious protection. Passive skin allergy test in rats, allergic shock in guinea pigs and isolated ileal allergic contraction test in guinea pigs, the volatile oils all showed significant anti-allergic effects, and at the same time there was a clear antagonistic effect on slow contracting substances in guinea pig intestinal contraction. It shows that the anti-asthmatic effect is related to the formation and release of anti-allergic agents in addition to the expansion of the bronchus.
2. Anti-arrhythmic effect of gavage of mice ginger oil 0.3ml/kg, continuous 3d, can significantly reduce the incidence of ventricular fibrillation caused by chloroform, energy against gallium chloride caused by arrhythmias, chlorination The arrhythmia of the bidirectional tachycardia in rats induced by sputum rapidly returned to normal sinus rhythm, and the dose and lethal dose of arrhythmia caused by aconitine increased, but the statistic was not significant. G caused by arrhythmia is not antagonistic.
3. Antifungal effects 0.005% -0.01% of wood ginger oil can inhibit 9 kinds of dermatophytes such as Brassica juncea, Trichophyton hirsutum, Epidermophyton floccosum, Plasporidium sp. 0.033%-0.1% can also inhibit Candida albicans, Cryptococcus neoformans, Sporothrix spp., and several skin-coloring fungi (Frankly's coloring fungi, Cladosporium callosum, Fusarium solani, Trichoderma viride, etc.). Only the antibacterial activity of Aspergillus flavus is weak, until the concentration is increased to 1% to inhibit Aspergillus flavus and Aspergillus fumigatus. In addition to bacteriostasis, wood ginger oil still has a certain degree of bactericidal effect. It is preliminarily considered that the antibacterial active ingredient is citral and the like.
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