What are the main equipments in the solid preparation workshop?
First, the crushing equipment
(1) Universal high-efficiency pulverizer: The high-speed relative motion between the movable toothed disc and the fixed sprocket wheel is used to crush the object, and the pulverization is obtained by a combination of gear impact, friction and impact between materials. There 20B, 30B, 40B type
(2) High-speed rotary impact pulverizer: According to the different mechanical structure, it can be simply divided into hammer type, lock type, rotary disc type, axial flow type, etc.; Horizontal. The high-speed rotating wheel disc is used to violently strike or impact the material, so that high-frequency mutual impact, shearing and the like are generated between the materials to achieve the purpose of crushing.
(3) Ball mill: According to its movement mode, it can be divided into ordinary horizontal ball mill, horizontal reverse rotary ball mill, vibrating ball mill, new high-fine ball mill and so on. The ball mill has the characteristics of good sealing, dust is not easy to fly, etc. It has strong adaptability to materials, continuous production, large production capacity, and easy to adjust the hungry fineness of the grinding products. It can be dry or wet, and can be dried. Simultaneously combined with grinding.
Second, the mixing equipment
Mixing equipment includes: EYH two-dimensional motion mixer, HD multi-directional motion mixer, FZH square cone mixer, HTD hopper mixer, CH tank mixer, LH fast mixer and so on.
Third, granulation equipment
(1) High-speed stirring granulator: The raw materials, auxiliary materials and adhesives are added into a container, and the mixing and granulation are quickly completed by adjusting the stirring, shearing, compaction and the like of the rotating agitator.
(2) Boiling granulation dryer or one-step granulation: mixing, granulation, and drying are completed in one equipment. Granulation mainly relies on the bridging action of the binder to bond the powders to each other. By boiling granulation, improving fluidity and reducing dust flying are beneficial to the implementation of GMP .
Fourth, drying equipment
(1) Hot air circulation oven: using steam and electricity as a heat source, heated by a heater, a large amount of hot air is circulated in the tank, and fresh air is continuously replenished from the air inlet into the tank, and then continuously discharged from the drain port, increasing heat transfer. The effect is to gradually reduce the moisture content of the material in the box; if the far-infrared quartz tube is used as the heating element, the thermal efficiency is high and the sanitary condition is good.
(2) Use GMP oven: The heat source has three modes: steam, electricity and electricity. The temperature can be automatically controlled and recorded by a recorder. High-efficiency gas filter for air inlet and medium efficiency filter for moisture outlet
Five, tableting equipment
(1) Single punching machine: The machine is equipped with a pair of die, Zui large from the piece diameter 12mnl , Zui large filling depth 11mm , production capacity 80 - 100 pieces / min , suitable for laboratory trial production or small batch production.
(2) Rotary tablet press: According to the number of holes on the turntable, it is divided into 19 punches, 21 punches, 27 punches, 33 punches, 37 punches, 55 punches, 75 punches, and the capacity is up to 5600 pieces /min . At present, most of the pharmaceutical companies use a rotary tablet press with mechatronics, high-speed, full-process control, and automatic chipping.
(3) High-speed double-track tablet press: controlled by computer, double-pressure and closed operation when pressing, which is superior to ordinary tablet press in all aspects, which can guarantee product quality.
Sixth, efficient coating machine
The core of the core is continuously traversed in the rotating drum of the coating machine, and the coating liquid is sprayed from the inlet spray gun to the surface of the core. At the same time, under the action of exhaust and negative pressure, the 100000 -level clean hot air supplied by the hot air cabinet is discharged from the damper through the core, and the coating medium is quickly and uniformly dried on the surface of the core to form a firm, dense and smooth surface film. The entire process is done automatically under program control. For example, BGB350 high-efficiency coating machine, Zui large coating weight 350KG , Zui large volume 480L , 5 spray guns alone, the flow between the guns is uniform, and the use of air atomization, atomization uniform particle size.
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