Release date: 2014-08-25
Active biomaterials that are tightly bound to growth factors can be used not only in bone materials, but also in the fields of skin, blood vessels, and nerves.
In the future, when people are injured in a certain part, they can replace the new “parts and accessories†at any time. This is the vision that can be brought about by implantable biomaterials in regenerative medicine.
The close-up is that the Dai Jianwu Research Group of the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, cooperated with Yantai Zhenghai Biotechnology Co., Ltd. (hereinafter referred to as Zhenghai Biotechnology) to successfully develop and realize collagen biomaterials, one of the most widely used implantable biomaterials. The bio-bone of industrial transformation has completed all clinical trials. It is expected that the product registration certificate will be obtained by the end of this year and will be sold in early 2015. This means that people can finally use the bone filling materials with reasonable price and advanced technology to feel the new experience brought about by the development of regenerative medicine.
"1.0 version" biological bone is expected to be put into production
According to reports, collagen plays an important role in wound repair and is the main structural protein involved in wound healing. Bio-bone material containing collagen is different from traditional bone material. The main component of traditional bone-filling material is hydroxyapatite, such as coral. The bone filling material is hard and brittle, while the biological bone filling material contains collagen and inorganic bone. Like a "sponge" with pores, it is very tough.
"In addition, the biological bone can also provide a three-dimensional scaffold for tissue cell growth, while filling and replacing the damaged part, promoting cell adhesion, proliferation and even differentiation." Institute of Genetics and Developmental Biology, Institute of Tissue Engineering Research, Chinese Academy of Sciences Director Dai Jianwu introduced the reporter of the Chinese Journal of Science.
After many investigations, Zhenghai Biotech confirmed the first application scope of collagen bio-bone products in product transformation: filling and repair of bone related diseases such as implants, maxillofacial surgery, periodontal disease, including dental implant surgery Preparation of implant beds, bone defect filling, maxillary sinus lift, etc.
Zhang Wencai, general manager of Zhenghai Biotechnology, told the reporter of the Chinese Journal of Science and Technology that the annual production of the collagen bio-bone product can reach 30,000 bottles (0.25g/bottle) at the initial stage of the market, and the market value of the initial market is about 30 million yuan. year.
Moreover, this is only the "1.0 version" of collagen bio-bone. The collagen bio-bone "2.0 version" with bone growth factor is in clinical trials. Once listed, active bone materials will be a blockbuster in the field of bone regeneration.
"2.0 version" active bone is more expected
According to Dai Jianwu, the "2.0 version" of the biological bone is also called active biological bone. Unlike the first generation of biological bone, scientists have genetically engineered a collagen-binding region that specifically binds collagen to bone growth factors. A bone growth factor capable of specifically binding to the collagen material is prepared, and the bone growth factor is directionally anchored to the collagen biological bone material.
Bone growth factor and collagen biobone material are not simply “one shot fitâ€. Chen Bing, a researcher at Dai Jianwu's laboratory, said that growth factors that are simply mixed with biological bones are prone to spread in body fluid infiltration, with adverse consequences.
"One is that the diffusion of growth factors poses a potential risk to the body. Second, the spread causes cell activity to occur mainly outside the material, resulting in limited repair effects, and in order to enhance the repair effect, repeated use of drugs is required, which undoubtedly increases costs and patients. Pain." Chen Bing said.
For the first time, Dai Jianwu's research team has innovatively established a growth factor release method for collagen biomaterials, which not only firmly binds growth factors to collagen bio-bone, but also establishes a sustained-release mechanism.
Dai Jianwu explained this "mystery": they found in their previous research results that a protein sequence on collagenase can bind collagen, and a protein sequence can cleave collagen, so they can combine collagen sequence and growth factor. Connected together, the growth factor grows a "tail" that recognizes collagen and selectively binds collagen.
"Such growth factors can be directly metabolized, and the maintenance time in the tissue is about a few days or tens of hours. It also acts as a stimulus signal, stimulates cell differentiation and angiogenesis, and can quickly repair the general The damage and trauma, compared to ordinary bone materials, the dose of bone growth factor used will be much less." Dai Jianwu said.
Zhenghai Biology, which undertakes the conversion of active bone products, also has great expectations for the “2.0 versionâ€. "Active biological bone can solve the problem of large bone defect and nonunion in clinical clinic. At present, we have carried out clinical trials in many centers across the country, and more than 80 patients with bone defects have been treated with active bone. The feedback is good, compared with the "1.0 version", it has more advantages." Zhang Wencai said.
Active biomaterials are widely used
What is even more desirable is that active biomaterials that are tightly bound to growth factors can be used not only in bone materials, but also in the fields of skin, blood vessels, and nerves. Different collagen materials can be prepared for different injuries, and the growth factors suitable for the repair of the tissue damage can be modified to have collagen binding ability.
Chen Bing et al. mentioned in the study that growth factors with different collagen binding ability and different collagen materials constitute functional collagen biomaterials suitable for different tissue damage repair, and in skin, bone, muscle (bladder muscle, abdominal wall muscles) ), the role of collagen-functional biomaterials in the repair of peripheral nerve and central nervous system injuries.
In Dai Jianwu's lab, the reporter saw the "collagen membrane" contained in a glass bottle. According to reports, the researchers have modified the activation factor of skin damage and successfully combined with collagen. This collagen membrane can be used as a wound covering, which has the characteristics of closed wound, moisturizing, hemostasis and absorbability. For example, it can help repair ulcers.
It is reported that the reason why the ulcer can not heal quickly is that there are more bacterial infections, and the blood circulation under the wound is not smooth. The traditional ulcer paste mainly contains antibiotics, which only solves one problem, that is, bacterial infection.
"If you want to design a ulcer patch with collagen membrane, I think there must be both growth factors and antibiotics. At the same time, it is divided into two layers, the first layer is antibiotics, inhibiting bacterial growth; the second layer is slow release growth factor. To promote healing, but the reverse is not possible, because if the growth factor first encounters bacteria, it will be degraded by the collagenase secreted by the bacteria." Dai Jianwu explained.
However, he then smiled lightly. "This is just a small direction that may be applied to life. It can be done too much. The Chinese Academy of Sciences Stem Cell and Regenerative Medicine Strategy Pilot specializes in a series of forward-looking products, in addition to active bone materials. There are myocardial regeneration products, nerve repair products, etc. We will also launch a series of research results in the future." Dai Jianwu said.
Source: Chinese Journal of Science (2014-07-29 8th Edition Biology)
Source: Chinese Journal of Science and Technology
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