Is the ultra-efficient nanomachine engine actually made of DNA?

Release date: 2016-07-19

Recently, Canadian researchers have pioneered a method of using DNA as a micro-machine engine to detect viruses, bacteria, cocaine and even metal substances.

John Brennan, president of the Canadian Institute of Bioanalytical Chemistry and Biointerfaces, said that the new platform can be adapted to many applications and DNA nanostructures are highly adaptable, so Can be used to detect a wide variety of target organisms.

The most famous genetic material is DNA, which is also a suitable molecule for programming and has important applications in the field of engineering synthesis. The new method can turn the separately programmed DNA material into a pair of interlocking circular objects. The first round is not activated until it is released by the second round.

Brennan says the key to this approach is that it can be selectively activated by any substance that needs to be detected. Researchers have now designed "locks" for a key, all components are made up of DNA, and will eventually be defined by the researchers on how to construct the substance.

Li Yingfu, chairman of the Canadian nucleic acid research team who participated in the study, explained that the idea of ​​DNA nanomachines comes from nature, and that organisms use various nanoscale molecular machines to achieve important cellular functions. This is the first time researchers have designed a DNA-based nanomachine that enables ultra-sensitive detection of a bacterial pathogen. Researchers are now developing DNA nanomachines into user-friendly testing tools that enable rapid detection of a wide range of substances and clinical trials within a year.

Source: People's Network

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