Second generation sequencing is still the mainstream
The development of the sequencer is mainly divided into three stages (three generations). The era of the sequencer was opened with the first commercial automatic sequencer in 1987. In 2005, 454 Life Technology Corporation released the 454 sequencing platform to open the second generation sequencing era. The PacBio RS launched by Pacific Biosciences in 2013 marks the arrival of three generations of sequencing. After decades of development, with the advantages of high precision and high throughput, the second generation sequencing has become the mainstream sequencing platform in the gene sequencing market.
In the fierce market competition, Roche did not play the leading edge of the 454 sequencing platform, and was forced to announce 100 layoffs in 2013 and close the 454 business. Roche did not give up the market for the sequencer. In June 2014, Roche acquired Genia Technologies, a third-generation sequencing company, for $350 million. Roche has focused on the next three generations of sequencing markets. However, the problem of high error rate of the three-generation sequencer has been delayed, and there is no hope to replace the second-generation sequencer in a short time.
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