Release date: 2014-09-30
Earlier this year, Illumina CEO Jay Flatley released two sequencers with confidence at the JPMorgan Health Conference, although the new instrument, HiseqXTen, has advantages over its previous sequencers in terms of throughput and speed of gene sequencing, but is expensive. The price has made many big companies shy and hopeless. And a $900-only sequencer is likely to make illumina feel awkward, as well as the owners of CG sequencers, because their sequencers weigh several tons and the average read length is only There is 36bp.
Developed by the British company OxfordNanopore, the MinION sequencer has a long read length and is only available in the size of an ordinary U disk. In theory, it can be measured. The sequencer has been put into the market a few days ago, and in the future it will become as common, convenient and cheap as a mobile phone.
The sequencing principle of MinION sequencer
The MinION sequencer is only 4 inches long and is the size of a normal U disk. It consists of a sensor chip, an ASIC and a complete flow control system for single-molecule sensing. MinION uses a novel nanopore sequencing method (nanoporesequencing) with a long read length, an average read length of 80Kbp, and a high sequencing speed.
However, the current low accuracy of nanopore sequencing is 65%-80%, which is still a concern, but the device is still being updated. Many researchers are very optimistic about this technology. "A few years later, It will dominate the genetic sequencing market." The technology was also named "one of the top 10 scientific breakthroughs in 2012" by MIT Technology Review magazine. Pharmaceutical giant Roche is also optimistic about this technology. In 2012, Roche announced that the gene sequencer 454 has withdrawn from the sequencing market, but they did not give up the sequencing market. Then they spent $125 million to acquire nano-sequencing technology company GeniaTechnologies and invested in StratosGenomics. the company.
The MinION sequencer is priced at just $900, and the genetic sequencer will win more markets in the future than the $50,000 to $750,000 gene sequencing equipment. You can put it in your pocket and sequence your genes anytime, anywhere, but data analysis for gene sequencing requires powerful computers and professionals to interpret them.
Despite this, its emergence will change the current rules of the game in the field of gene sequencing. The days of large-scale gene sequencing equipment vendors and gene sequencing services companies will become embarrassing because people will no longer need their equipment, instruments and services, and genetic sequencing companies may get angry because of huge genetic sequencing data. More companies are needed to complete the task of genetic interpretation.
Source: Health
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